Viewing single variant in MT-TD

Uncertain Significance (VUS)Not in ClinVar or MITOMAP — mtDNA classification needs case-level review

MT-TD:m.7551A>G

Tutor Research

Nomenclaturem.7551A>GchrMT:7551|Not in ClinVar

Typemitochondrial tRNA variant

InheritanceMitochondrial

gnomAD mtDNA

4 hom · 0 het

of 56,434 genomes

MitoTIP

9.4 · Q3 possibly benign

PON-mt-tRNA

0.32 · likely neutral

Tutor Research

MITOMAPReported

Live entry

Disease: Maternally inherited or aminoglycoside-induced deafness (DEAF) increased penetrance (1555G helper)Reported as: homoplasmicGenBank: 2 sequences

MITOMAP (mitomap.org), CC BY 3.0 · disease table as of 2026-10-07

Where it sits in the mitochondrial genome

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proteinrRNAtRNAouter ring H-strand · inner L-strandMITOMAP confirmedreported (as of 2026-10-07)

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AACCATTTCATAACTTTGTCAAAGTTAAATTATAGGCTAAA

MT-TD

m.7531–7571 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.7551 A→G.

37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.