MT-TC:m.5774T>C

Tutor Research

Nomenclaturem.5774T>CchrMT:5774|ClinVar #689983

Typemitochondrial tRNA variant

InheritanceMitochondrial

gnomAD mtDNA

27 hom · 1 het

of 56,420 genomes

MitoTIP

1.2 · Q4 likely benign

PON-mt-tRNA

0.21 · neutral

Tutor Research

ClinVarBenign

VCV000689983

Review: criteria provided, single submitterSubmitters: 1view ↗Last evaluated: 2019/07/12 00:00

MELAS syndrome[OMIM][MedGen][Orphanet][MONDO]

MITOMAPReported

Live entry

Disease: Reported in tic disorder patientGenBank: 73 sequences

MITOMAP (mitomap.org), CC BY 3.0 · disease table as of 2026-10-07

Where it sits in the mitochondrial genome

Tap or hover a gene, landmark or tick; genes open their page, ticks their variant.

proteinrRNAtRNAouter ring H-strand · inner L-strandMITOMAP confirmedreported (as of 2026-10-07)

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GCGGGAGAAGCCCCGGCAGGTTTGAAGCTGCTTCTTCGAAT

MT-TC (L-strand) · starts m.5761

m.5754–5794 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.5774 T→C.

37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.

Open Research Assistant for MT-TC →

External Resources

Franklin (Genoox)

AI-powered curation

MITOMAP

mtDNA variant database · expect a security check

VarSome

Variant interpretation · expect a security check

OMIM

Gene & phenotype

gnomAD

mtDNA frequencies (v3.1)

UCSC Browser

Genome browser

m.5774T>C

Resolving variant against ClinVar, gnomAD and Ensembl…

MT-TC:m.5774T>C

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources

MT-TC:m.5774T>C

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources