MT-TC:m.5780G>A

Tutor Research

Nomenclaturem.5780G>AchrMT:5780|ClinVar #689986

Typemitochondrial tRNA variant

InheritanceMitochondrial

gnomAD mtDNA

32 hom · 0 het

of 56,434 genomes

MitoTIP

10.7 · Q3 possibly benign

PON-mt-tRNA

0.12 · neutral

Tutor Research

ClinVarBenign

VCV000689986

Review: criteria provided, single submitterSubmitters: 1view ↗Last evaluated: 2019/07/12 00:00

MELAS syndrome[OMIM][MedGen][Orphanet][MONDO]

MITOMAPReported

Live entry

Disease: Sensorineural hearing loss (SNHL)Reported as: heteroplasmicGenBank: 25 sequences

MITOMAP (mitomap.org), CC BY 3.0 · disease table as of 2026-10-07

Where it sits in the mitochondrial genome

Tap or hover a gene, landmark or tick; genes open their page, ticks their variant.

proteinrRNAtRNAouter ring H-strand · inner L-strandMITOMAP confirmedreported (as of 2026-10-07)

|||||

GAAGCCCCGGCAGGTTTGAAGCTGCTTCTTCGAATTTGCAA

MT-TC (L-strand) · starts m.5761

m.5760–5800 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.5780 G→A.

37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.

Open Research Assistant for MT-TC →

External Resources

Franklin (Genoox)

AI-powered curation

MITOMAP

mtDNA variant database · expect a security check

VarSome

Variant interpretation · expect a security check

OMIM

Gene & phenotype

gnomAD

mtDNA frequencies (v3.1)

UCSC Browser

Genome browser

m.5780G>A

Resolving variant against ClinVar, gnomAD and Ensembl…

MT-TC:m.5780G>A

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources

MT-TC:m.5780G>A

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources