MT-TG

Chr MT

tRNA-Gly

Also known as: MTTG

NCBI Gene: 4563ENSG00000210164
46
ClinVar variants
16
Pathogenic / LP
—
pLI score
2
Active trials
Clinical Summary— MT-TG
🧬
Gene-Disease Validity (ClinGen)
mitochondrial disease · MTModerate

Moderate evidence — consider for supplementary testing

📋
ClinVar Variants
16 Pathogenic / Likely Pathogenic· 14 VUS of 46 total submissions
💊
Clinical Trials
2 active or recruiting trials — potential therapeutic options may be available

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

46 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic14
Likely Pathogenic2
VUS14
Likely Benign6
Benign10
14
Pathogenic
2
Likely Pathogenic
14
VUS
6
Likely Benign
10
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————14
Likely Pathogenic
————2
VUS
————14
Likely Benign
————6
Benign
————10
Total—46

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

MT-TG · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
B Acute Lymphoblastic Leukemia

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

RECRUITING
NCT06124157Phase PHASE3National Cancer Institute (NCI)Started 2025-05-30
Biospecimen CollectionBlinatumomabBone Marrow Biopsy
Acute Leukemia of Ambiguous LineageB Acute Lymphoblastic Leukemia

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

RECRUITING
NCT06317662Phase PHASE2National Cancer Institute (NCI)Started 2025-06-05
Asparaginase Erwinia chrysanthemiBiospecimen CollectionBlinatumomab

External Resources

Links to major genomics databases and tools