MT-TT
Chr MTtRNA-Thr
Also known as: MTTT
Predicted to enable triplet codon-amino acid adaptor activity. Predicted to be involved in translation. [provided by Alliance of Genome Resources, Jul 2025]
Clinical highlights
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
MT-TT is a mitochondrial tRNA gene. gnomAD constraint, carrier burden and exome coverage, the ClinVar type breakdown, the protein lollipop, AlphaFold and transcript-architecture views are built for nuclear genes and are not shown. Population data for mtDNA variants (gnomAD v3.1, homoplasmy and heteroplasmy) is on each variant page.
Where it sits in the mitochondrial genome
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37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.
ClinVar Variant Classifications
0 submitted variants in ClinVar
MITOMAP Disease Variants — MT-TT
Live table ↗| Variant | Disease | Status | GenBank seqs |
|---|---|---|---|
| m.15894G>A | Gout | Reported | 43 |
| m.15897G>A | Maternally inherited diabetes (MID) | Reported | 0 |
| m.15901A>G | Hearing loss patient | Reported | 11 |
| m.15902A>G | Hearing loss patient | Reported | 10 |
| m.15904C>T | Protective factor for stroke risk (hg V) | Reported | 1,026 |
| m.15908T>C | DEAF helper mutation | Reported | 277 |
| m.15909A>G | Hypertension | Reported | 6 |
| m.15910C>T | Tic disorder patient / hearing loss patient / coronary heart disease | Reported | 34 |
| m.15915G>A | Encephalomyopathy | Uncertain significance · reported | 1 |
| m.15923A>G | LIMM / MERRF / mito disease | Likely pathogenic · confirmed | 0 |
| m.15924A>G | LIMM / PCOS patients | Reported | 2,320 |
| m.15926C>T | Hearing loss patient | Reported | 9 |
| m.15927G>A | LHON / Multiple Sclerosis / DEAF1555 increased penetrance / CHD | Reported | 638 |
| m.15928G>A | Multiple Sclerosis / idiopathic repeat miscarriage / AD protection | Reported | 3,320 |
| m.15930G>A | Possible DEAF risk factor / PCOS patients | Reported | 1,491 |
| m.15933G>A | Suspected mito disease | Reported | 0 |
| m.15942T>C | Possibly LVNC-associated | Reported | 520 |
| m.15944T>- | MM | Conflicting reports | 1,051 |
| m.15948A>G | Reported in tic disorder patient | Reported | 8 |
| m.15950G>A | LHON / LHON-MS / dopaminergic nerve cell death (PD) / tic disorder | Reported | 4 |
| m.15951A>G | LHON / LHON modulator | Conflicting reports | 445 |
| m.15952C>T | Reported in tic disorder patient | Reported | 7 |
As of 2026-10-07 — a dated copy; MITOMAP can’t be fetched live, and the live table may be newer.
Source: MITOMAP (mitomap.org), CC BY 3.0
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools