MT-CO3
Chr MTcytochrome c oxidase subunit III
Also known as: COIII, MTCO3
Predicted to contribute to cytochrome-c oxidase activity. Involved in respiratory chain complex IV assembly. Located in mitochondrial membrane. Part of respiratory chain complex IV. Implicated in MELAS syndrome. [provided by Alliance of Genome Resources, Apr 2025]
Primary Disease Associations & Inheritance
UniProtLeber hereditary optic neuropathy
UniProtMitochondrial complex IV deficiency
UniProtRecurrent myoglobinuria mitochondrial
Clinical highlights
Gene-disease validity (ClinGen)
Leigh syndrome · MTLimitednot for standalone diagnostic reporting2 gene-disease associations curated in total
📖
Open GeneReview ↗GeneReview available — MT-CO3
Authoritative clinical overview · Recommended first read
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MT-CO3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
📖
Open GeneReview ↗GeneReview available — MT-CO3
Authoritative clinical overview · NCBI Bookshelf · Recommended first read
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools