Viewing single variant in MT-TG

Uncertain Significance (VUS)Not in ClinVar or MITOMAP — mtDNA classification needs case-level review

MT-TG:m.10057T>C

Tutor Research

Nomenclaturem.10057T>CchrMT:10057|Not in ClinVar

Typemitochondrial tRNA variant

InheritanceMitochondrial

gnomAD mtDNA

0 hom · 1 het

of 56,433 genomes

MitoTIP

11.3 · Q3 possibly benign

PON-mt-tRNA

0.43 · likely neutral

Tutor Research

MITOMAPReported

Live entry

Disease: Hearing loss patientGenBank: 6 sequences

MITOMAP (mitomap.org), CC BY 3.0 · disease table as of 2026-10-07

Where it sits in the mitochondrial genome

Tap or hover a gene, landmark or tick; genes open their page, ticks their variant.

proteinrRNAtRNAouter ring H-strand · inner L-strandMITOMAP confirmedreported (as of 2026-10-07)

||||

TGACAACATTCAAAAAAGAGTAATAAACTTCGCCTTAATTT

MT-TG · ends m.10058

MT-ND3 · starts m.10059

m.10037–10077 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.10057 T→C.

37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.

Open Research Assistant for MT-TG →

External Resources

Franklin (Genoox)

AI-powered curation

MITOMAP

mtDNA variant database · expect a security check

VarSome

Variant interpretation · expect a security check

OMIM

Gene & phenotype

gnomAD

mtDNA frequencies (v3.1)

UCSC Browser

Genome browser

m.10057T>C

Resolving variant against ClinVar, gnomAD and Ensembl…

MT-TG:m.10057T>C

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources

MT-TG:m.10057T>C

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources