MT-TM
Chr MTtRNA-Met
Also known as: MTTM
Clinical highlights
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
MT-TM is a mitochondrial tRNA gene. gnomAD constraint, carrier burden and exome coverage, the ClinVar type breakdown, the protein lollipop, AlphaFold and transcript-architecture views are built for nuclear genes and are not shown. Population data for mtDNA variants (gnomAD v3.1, homoplasmy and heteroplasmy) is on each variant page.
Where it sits in the mitochondrial genome
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37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.
ClinVar Variant Classifications
0 submitted variants in ClinVar
MITOMAP Disease Variants — MT-TM
Live table ↗| Variant | Disease | Status | GenBank seqs |
|---|---|---|---|
| m.4403G>A | Mitochondrial myopathy | Reported | 0 |
| m.4409T>C | Mitochondrial myopathy | Uncertain significance · reported | 0 |
| m.4410C>A | Poss. hypertension factor | Reported | 0 |
| m.4412G>A | Seizures with myopathy & retinopathy | Reported | 0 |
| m.4414T>C | Progressive external ophthalmoplegia and myopathy | Reported | 0 |
| m.4415A>G | EXIT & APS2 | Reported | 0 |
| m.4435A>G | LHON / LHON modulator / hypertension; autism spectrum; intellectual disability / hearing loss | Reported | 61 |
| m.4437C>T | Hypotonia, seizure, muscle weakness, lactic acidosis, hearing loss | Uncertain significance · reported | 0 |
| m.4440G>A | Mitochondrial myopathy | Reported | 0 |
| m.4450G>A | Myopathy / MELAS / Leigh Syndrome / EXIT | Likely pathogenic · confirmed | 0 |
| m.4452T>C | Reported in tic disorder patient | Reported | 129 |
| m.4454T>C | Possible contributor to mito dysfunction / hypertension / PCOS patient | Reported | 251 |
| m.4456C>T | Poss. hypertension factor | Reported | 6 |
| m.4467C>A | Maternally inherited hypertension | Reported | 0 |
As of 2026-10-07 — a dated copy; MITOMAP can’t be fetched live, and the live table may be newer.
Source: MITOMAP (mitomap.org), CC BY 3.0
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Trials that enrol by condition rarely name the gene: mitochondrial disease
External Resources
Links to major genomics databases and tools