MT-TY:m.5877C>T

Tutor Research

Nomenclaturem.5877C>TchrMT:5877|ClinVar #9552

Typemitochondrial tRNA variant

InheritanceMitochondrial

gnomAD mtDNA

Absent

of 56,433 genomes

MitoTIP

8.4 · Q4 likely benign

PON-mt-tRNA

0.73 · pathogenic

Tutor Research

ClinVarUncertain significance

VCV000009552

Review: reviewed by expert panelSubmitters: 2view ↗Last evaluated: 2024/06/24 00:00

Mitochondrial disease[MedGen][Orphanet][MONDO]

MITOMAPUncertain significancereported

Live entry

Disease: Chronic progressive external ophthalmoplegia (CPEO)Reported as: heteroplasmicGenBank: 0 sequences

MITOMAP (mitomap.org), CC BY 3.0 · disease table as of 2026-10-07

Where it sits in the mitochondrial genome

Tap or hover a gene, landmark or tick; genes open their page, ticks their variant.

proteinrRNAtRNAouter ring H-strand · inner L-strandMITOMAP confirmedreported (as of 2026-10-07)

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ATTTACAGTCCAATGCTTCACTCAGCCATTTTACCTCACCC

MT-TY (L-strand) · ends m.5891

m.5857–5897 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.5877 C→T.

37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.

Open Research Assistant for MT-TY →

External Resources

Franklin (Genoox)

AI-powered curation

MITOMAP

mtDNA variant database · expect a security check

VarSome

Variant interpretation · expect a security check

OMIM

Gene & phenotype

gnomAD

mtDNA frequencies (v3.1)

UCSC Browser

Genome browser

m.5877C>T

Resolving variant against ClinVar, gnomAD and Ensembl…

MT-TY:m.5877C>T

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources

MT-TY:m.5877C>T

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources