Viewing single variant in MT-TP

Uncertain Significance (VUS)Not in ClinVar or MITOMAP — mtDNA classification needs case-level review

MT-TP:m.15992A>G

Tutor Research

Nomenclaturem.15992A>GchrMT:15992|Not in ClinVar

Typemitochondrial tRNA variant

InheritanceMitochondrial

gnomAD mtDNA

4 hom · 1 het

of 56,434 genomes

MitoTIP

6.5 · Q4 likely benign

PON-mt-tRNA

0.32 · likely neutral

Tutor Research

MITOMAPReported

Live entry

Disease: Maternally inherited hypertension · Tic disorder patient · Hearing loss patientGenBank: 5 sequences

MITOMAP (mitomap.org), CC BY 3.0 · disease table as of 2026-10-07

Where it sits in the mitochondrial genome

Tap or hover a gene, landmark or tick; genes open their page, ticks their variant.

proteinrRNAtRNAouter ring H-strand · inner L-strandMITOMAP confirmedreported (as of 2026-10-07)

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TAACTCCACCATTAGCACCCAAAGCTAAGATTCTAATTTAA

MT-TP (L-strand)

m.15972–16012 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.15992 A→G.

37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.

Open Research Assistant for MT-TP →

External Resources

Franklin (Genoox)

AI-powered curation

MITOMAP

mtDNA variant database · expect a security check

VarSome

Variant interpretation · expect a security check

OMIM

Gene & phenotype

gnomAD

mtDNA frequencies (v3.1)

UCSC Browser

Genome browser

m.15992A>G

Resolving variant against ClinVar, gnomAD and Ensembl…

MT-TP:m.15992A>G

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources

MT-TP:m.15992A>G

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources