Viewing single variant in MT-TR

Uncertain Significance (VUS)Not in ClinVar or MITOMAP — mtDNA classification needs case-level review

MT-TR:m.10415T>C

Tutor Research

Nomenclaturem.10415T>CchrMT:10415|Not in ClinVar

Typemitochondrial tRNA variant

InheritanceMitochondrial

gnomAD mtDNA

Absent

of 56,432 genomes

MitoTIP

16.4 · Q1 likely pathogenic

PON-mt-tRNA

0.58 · likely pathogenic

Tutor Research

MITOMAPReported

Live entry

Disease: Dilated CardiomyopathyReported as: homoplasmicGenBank: 0 sequences

MITOMAP (mitomap.org), CC BY 3.0 · disease table as of 2026-10-07

Where it sits in the mitochondrial genome

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proteinrRNAtRNAouter ring H-strand · inner L-strandMITOMAP confirmedreported (as of 2026-10-07)

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TGAACCGAATTGGTATATAGTTTAAACAAAACGAATGATTT

MT-ND3 · ends m.10404

MT-TR · starts m.10405

m.10395–10435 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.10415 T→C.

37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.

Open Research Assistant for MT-TR →

External Resources

Franklin (Genoox)

AI-powered curation

MITOMAP

mtDNA variant database · expect a security check

VarSome

Variant interpretation · expect a security check

OMIM

Gene & phenotype

gnomAD

mtDNA frequencies (v3.1)

UCSC Browser

Genome browser

m.10415T>C

Resolving variant against ClinVar, gnomAD and Ensembl…

MT-TR:m.10415T>C

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources

MT-TR:m.10415T>C

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources