MT-TT:m.15894G>A

Tutor Research

Nomenclaturem.15894G>AchrMT:15894|ClinVar #690218

Typemitochondrial tRNA variant

InheritanceMitochondrial

gnomAD mtDNA

14 hom · 4 het

of 56,429 genomes

MitoTIP

9.2 · Q3 possibly benign

PON-mt-tRNA

0.57 · likely pathogenic

Tutor Research

ClinVarBenign/Likely benign

VCV000690218

Review: criteria provided, multiple submitters, no conflictsSubmitters: 2view ↗Last evaluated: 2025/02/16 00:00

not specified[MedGen]

MELAS syndrome[OMIM][MedGen][Orphanet][MONDO]

MITOMAPReported

Live entry

Disease: GoutReported as: homoplasmicGenBank: 43 sequences

MITOMAP (mitomap.org), CC BY 3.0 · disease table as of 2026-10-07

Where it sits in the mitochondrial genome

Tap or hover a gene, landmark or tick; genes open their page, ticks their variant.

proteinrRNAtRNAouter ring H-strand · inner L-strandMITOMAP confirmedreported (as of 2026-10-07)

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ACTCAAATGGGCCTGTCCTTGTAGTATAAACTAATACACCA

MT-CYB · ends m.15887

MT-TT · starts m.15888

m.15874–15914 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.15894 G→A.

37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.

Open Research Assistant for MT-TT →

External Resources

Franklin (Genoox)

AI-powered curation

MITOMAP

mtDNA variant database · expect a security check

VarSome

Variant interpretation · expect a security check

OMIM

Gene & phenotype

gnomAD

mtDNA frequencies (v3.1)

UCSC Browser

Genome browser

m.15894G>A

Resolving variant against ClinVar, gnomAD and Ensembl…

MT-TT:m.15894G>A

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources

MT-TT:m.15894G>A

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources