m.1494C>T
Resolving variant against ClinVar, gnomAD and Ensembl…
Resolving variant against ClinVar, gnomAD and Ensembl…
Avoid aminoglycoside antibiotics — risk of permanent hearing loss
Avoid aminoglycoside antibiotics unless the high risk of permanent hearing loss is outweighed by the severity of infection and there is no safe or effective alternative. CPIC: strong recommendation, high evidence.
Profound hearing loss has followed a single standard dose. Any heteroplasmy level counts — there is no safe threshold. Covers gentamicin, tobramycin, amikacin and the rest of the class.
CPIC guideline, McDermott et al. 2022 (PMID 34032273)
Tap or hover a gene, landmark or tick; genes open their page, ticks their variant.
m.1474–1514 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.1494 C→T.
37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.