MT-TR

Chr MT

tRNA-Arg

Also known as: MTTR

This gene encodes mitochondrial tRNA for arginine, which is essential for mitochondrial protein synthesis and oxidative phosphorylation. Mutations cause mitochondrial encephalomyopathy with variable clinical severity depending on heteroplasmy levels. Inheritance is maternal through mitochondrial DNA.

OMIMResearchSummary from Curated mito context
Clinical SummaryMT-TR
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Gene-Disease Validity (ClinGen)
mitochondrial disease · MTModerate

Moderate evidence — consider for supplementary testing

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Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

MT-TR · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold
Clinical Literature
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