MT-TW
Chr MTtRNA-Trp
Also known as: MTTW
This gene encodes mitochondrial tRNA for tryptophan, which is essential for mitochondrial protein synthesis and oxidative phosphorylation. Mutations cause encephalomyopathy and Leigh syndrome through disruption of mitochondrial energy production. Inheritance is maternal, and clinical severity depends on the degree of heteroplasmy in affected tissues.
Definitive — sufficient evidence for diagnostic panels
2 total gene-disease associations curated
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MT-TW · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools