m.663A>G
Resolving variant against ClinVar, gnomAD and Ensembl…
Resolving variant against ClinVar, gnomAD and Ensembl…
Aminoglycosides: uncertain-risk MT-RNR1 variant (CPIC)
Weak or no evidence of increased risk: standard doses for the shortest feasible course with drug-level monitoring, and regular hearing checks. CPIC: optional recommendation · CPIC guideline, McDermott et al. 2022 (PMID 34032273)
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m.643–683 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.663 A→G.
37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.