MT-TC
Chr MTtRNA-Cys
Also known as: MTTC
Clinical highlights
MT-TC is a mitochondrial tRNA gene. gnomAD constraint, carrier burden and exome coverage, the ClinVar type breakdown, the protein lollipop, AlphaFold and transcript-architecture views are built for nuclear genes and are not shown. Population data for mtDNA variants (gnomAD v3.1, homoplasmy and heteroplasmy) is on each variant page.
Where it sits in the mitochondrial genome
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37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.
ClinVar Variant Classifications
0 submitted variants in ClinVar
MITOMAP Disease Variants — MT-TC
Live table ↗| Variant | Disease | Status | GenBank seqs |
|---|---|---|---|
| m.5774T>C | Reported in tic disorder patient | Reported | 73 |
| m.5780G>A | SNHL | Reported | 25 |
| m.5783G>A | Myopathy / deafness / gout / tic disorder | Reported | 49 |
| m.5789T>C | Late-onset NARP | Reported | 0 |
| m.5794T>C | Hearing loss/ tic disorder | Reported | 16 |
| m.5802T>C | DEAF1555 increased penetrance / obesity risk | Reported | 8 |
| m.5809G>A | Hearing loss patient | Reported | 1 |
| m.5814T>C | Encephalopathy / gout | Likely benign · reported | 273 |
| m.5816A>G | Progressive Dystonia | Uncertain significance · reported | 0 |
| m.5819T>C | Reported in tic disorder patient | Reported | 0 |
| m.5820C>A | MERRF | Reported | 0 |
| m.5821G>A | DEAF helper mut./ dilated cardiomyopathy | Reported | 397 |
| m.5822G>A | Hearing loss patient | Reported | 7 |
As of 2026-10-07 — a dated copy; MITOMAP can’t be fetched live, and the live table may be newer.
Source: MITOMAP (mitomap.org), CC BY 3.0
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools