Viewing single variant in MT-TN

Uncertain Significance (VUS)Not in ClinVar or MITOMAP — mtDNA classification needs case-level review

MT-TN:m.5670A>G

Tutor Research

Nomenclaturem.5670A>GchrMT:5670|Not in ClinVar

Typemitochondrial tRNA variant

InheritanceMitochondrial

gnomAD mtDNA

0 hom · 1 het

of 56,430 genomes

MitoTIP

8.2 · Q4 likely benign

PON-mt-tRNA

0.33 · neutral

Tutor Research

MITOMAPReported

Live entry

Disease: Progressive mitochondrial myopathyReported as: homoplasmicGenBank: 1 sequence

MITOMAP (mitomap.org), CC BY 3.0 · disease table as of 2026-10-07

Where it sits in the mitochondrial genome

Tap or hover a gene, landmark or tick; genes open their page, ticks their variant.

proteinrRNAtRNAouter ring H-strand · inner L-strandMITOMAP confirmedreported (as of 2026-10-07)

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GCCCTTACTAGACCAATGGGACTTAAACCCACAAACACTTA

MT-TA (L-strand) · ends m.5655

MT-TN (L-strand) · starts m.5657

m.5650–5690 of the revised Cambridge Reference Sequence (NC_012920.1); the boxed base is m.5670 A→G.

37 genes from Ensembl (rCRS numbering, matched to MITOMAP’s Gene Loci); landmarks and disease alleles from MITOMAP (CC BY 3.0). Circular layout after MitoWheel.

Open Research Assistant for MT-TN →

External Resources

Franklin (Genoox)

AI-powered curation

MITOMAP

mtDNA variant database · expect a security check

VarSome

Variant interpretation · expect a security check

OMIM

Gene & phenotype

gnomAD

mtDNA frequencies (v3.1)

UCSC Browser

Genome browser

m.5670A>G

Resolving variant against ClinVar, gnomAD and Ensembl…

MT-TN:m.5670A>G

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources

MT-TN:m.5670A>G

Where it sits in the mitochondrial genome

Population Allele Frequencies

External Resources