Genes associated with “DYT26”

70 genes foundOpen Targets: myoclonic dystonia 2614 ClinVar P/LP variants
How are genes scored? (0–100 composite)
-5–15
ClinGen
0–15
HPO Freq
0–15
Open Targets
0–12
Phen2Gene
0–10
ClinVar
0–8
Constraint
0–8
Dosage
0–8
OMIM CS
0–8
PanelApp
0–5
OMIM
0–5
G2P
0–4
Breadth
Tiers:Strong Candidates (≥20)Consider (≥8)Possible (≥3)
Evidence dots:
HPOClinVarPhen2GeneOpen TargetsPanelApp
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Strong Candidates

1 gene
1
KCTD17 →

potassium channel tetramerization domain containing 17

24
score
GTR ↑

Dystonia 26, myoclonic

Frequency
-
P/LP Variants
13
OT Score
0.66

Consider

8 genes
13DYT26

DYSTONIA 26, MYOCLONIC; DYT26

10RAC2
Str
9SOX10
Def
8CSNK1E
8DDX17
8ELFN2
8GGA1
8GTPBP1

Possible

52 genes — click to expand
7CSF2RB
Def
7IFT27
Def
7KMT2B
Def
7PLA2G6
Def
7TMPRSS6
Def
7TRIOBP
Def
6IL2RB
Mod
6ARX
Def

aristaless related homeobox

4MYO5A
Def

myosin VA

4ANKRD54
4BAIAP2L2
4C1QTNF6
4C22ORF23
4CARD10
4CBY1
4CDC42EP1
4CIMIP4
4CYTH4
4DMC1
4EIF3L
4FAM227A
4GALR3
4H1-0
4JOSD1
4KCNJ4
4KDELR3
4LGALS1
4LGALS2
4MICALL1
4MPST
No
4NCF4
4NOL12
4PICK1
4POLR2F
4PVALB
4SH3BP1
4SLC16A8
4SSTR3
4SUN2
4TMEM184B
4TOMM22
4DST
Def

dystonin

4ATP1A3
Def

ATPase Na+/K+ transporting subunit alpha 3

4PCDH15
Def

protocadherin related 15

4SCN8A
Def

sodium voltage-gated channel alpha subunit 8

4LAMA2
Def

laminin subunit alpha 2

4DYNC1H1
Def

dynein cytoplasmic 1 heavy chain 1

4PRRT2
Def

proline rich transmembrane protein 2

4GABRA1
Def

gamma-aminobutyric acid type A receptor subunit alpha1

4KCNQ1
DefSF

potassium voltage-gated channel subfamily Q member 1

4GABRG2
Def

gamma-aminobutyric acid type A receptor subunit gamma2

4RELN
Def

reelin

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Data aggregated from HPO/Monarch, ClinVar, OMIM (phenotypes + clinical synopsis), Open Targets, PanelApp, Phen2Gene, and Gene2Phenotype. Click a gene to view full details.