LGALS1

Chr 22

galectin 1

Also known as: GAL1, GBP

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
4
Active trials
81
Pubs (1 yr)
P/LP submissions
P/LP missense
1.54
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.54LOEUF
pLI 0.004
Z-score 0.67
OE 0.70 (0.341.54)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.45Z-score
OE missense 0.86 (0.711.05)
73 obs / 84.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.70 (0.341.54)
00.351.4
Missense OE?0.86 (0.711.05)
00.61.4
Synonymous OE?0.96
01.21.6
LoF obs/exp: 4 / 5.7Missense obs/exp: 73 / 84.8Syn Z: 0.17

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

LGALS1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.