GALR3

Chr 22

galanin receptor 3

NCBI Gene: 8484ENSG00000128310UniProt: O60755

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]

94
ClinVar variants
0
Pathogenic / LP
0.00
pLI score
0
Active trials
Clinical Summary— GALR3
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
📋
ClinVar Variants
94 total variants — no pathogenic classifications of 94 total submissions

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
1.71LOEUF
pLI 0.000
Z-score 0.18
OE 0.93 (0.50–1.71)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
0.21Z-score
OE missense 0.95 (0.83–1.09)
139 obs / 146.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.93 (0.50–1.71)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.95 (0.83–1.09)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.1.15
0≤1.21.6
LoF obs/exp: 6 / 6.5Missense obs/exp: 139 / 146.3Syn Z: -1.00

ClinVar Variant Classifications

94 submitted variants in ClinVar

ClinVar

Classification Summary

Protein Context — Lollipop Plot

GALR3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Galanin Receptors (GalR1, GalR2, and GalR3) Expression in Colorectal Cancer Tissue and Correlations to the Overall Survival and Poor Prognosis of CRC Patients.
Kiezun J et al.·Int J Mol Sci
2022Cohort
Prognostic genes related to mitochondrial dynamics and mitophagy in diffuse large B-cell lymphoma are identified and validated using an integrated analysis of bulk and single-cell RNA sequencing.
Chen Q et al.·Front Immunol
2025
The brain galanin receptors: targets for novel antidepressant drugs.
Lu X et al.·CNS Neurol Disord Drug Targets
2007Review
Galanin, galanin receptor subtypes and depression-like behaviour.
Kuteeva E et al.·Cell Mol Life Sci
2008Review
Galanin, galanin receptor subtypes and depression-like behaviour.
Kuteeva E et al.·Exp Suppl
2010Review
The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease.
Lang R et al.·Pharmacol Ther
2007Review
The role of galanin in the progression and prognosis of colorectal cancer: the unfinished story.
Kmiec Z et al.·Eur J Histochem
2024
Galanin expression is down-regulated in patients with gastric cancer.
Zhang L et al.·J Int Med Res
2019Cohort
The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.
Sugimoto T et al.·Genes Chromosomes Cancer
2009
Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status.
Perel Y et al.·Br J Cancer
2002
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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External Resources

Links to major genomics databases and tools