SLC16A8

Chr 22

solute carrier family 16 member 8

Also known as: MCT3, REMP

NCBI Gene: 23539ENSG00000100156UniProt: O95907

SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]

ResearchGenerating clinical summary…
0
Active trials
8
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.28
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.28LOEUF
pLI 0.009
Z-score 1.08
OE 0.56 (0.28–1.28)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.93Z-score
OE missense 0.84 (0.75–0.94)
221 obs / 263.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.56 (0.28–1.28)
0≤0.351.4
Missense OE?0.84 (0.75–0.94)
0≤0.61.4
Synonymous OE?1.02
0≤1.21.6
LoF obs/exp: 4 / 7.1Missense obs/exp: 221 / 263.4Syn Z: -0.19

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

SLC16A8 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients