H1-0

Chr 22

H1.0 linker histone

Also known as: H1.0, H10, H1F0, H1FV

NCBI Gene: 3005ENSG00000189060UniProt: P07305

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
12
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.90
LOEUF
LOF
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.90LOEUF
pLI 0.643
Z-score 1.69
OE 0.00 (0.00–0.90)
Moderately constrained

Typical tolerance to LoF variation

Missense Constraint?
0.88Z-score
OE missense 0.77 (0.65–0.92)
88 obs / 114.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.00 (0.00–0.90)
0≤0.351.4
Missense OE?0.77 (0.65–0.92)
0≤0.61.4
Synonymous OE?1.23
0≤1.21.6
LoF obs/exp: 0 / 3.3Missense obs/exp: 88 / 114.4Syn Z: -1.32

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

H1-0 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
ExerciseOverreachingButyrate

Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men

RECRUITING
NCT07481578Phase NAStefan De SmetStarted 2024-10-07
SupplementModerate load exercise trainingHigh load exercise training
Geriatric Health ServicesHealth Services for the Elderly

Cyber-Human Systems for Personalized Well-being and Health

RECRUITING
NCT06490783Istituto per la Ricerca e l'Innovazione BiomedicaStarted 2024-07-01
Noninvasive wearable devices (smartwatch and heart rate monitor band)
Fatigue

The Role of the Brain in Mental and Physical Fatigue

RECRUITING
NCT05880342Phase PHASE3Vrije Universiteit BrusselStarted 2023-05-03
Reboxetine PillMethylphenidate Oral Product
Obsessive - Compulsive DisorderTranscranial Magnetic StimilationIntermittent Theta Burst Stimulation

Electrophysiological Biomarkers and Treatment Response to Accelerated Transcranial Magnetic Stimulation in Patients With Obsessive-Compulsive Disorder

RECRUITING
NCT07561528Phase NAIstanbul University - CerrahpasaStarted 2026-01-01
iTBS TMS
Breast NeoplasmBreast CancerBreast Tumors

Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy

RECRUITING
NCT05582499Phase PHASE2Fudan UniversityStarted 2022-11-01
DalpiciclibPyrotinibSHR-A1811
CaregiversEmotionsEmotion Regulation

Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons With Alzheimer's Disease

RECRUITING
NCT05949047Phase NABryan DennyStarted 2023-09-14
Cognitive Emotion Regulation Training via Psychological DistancingCognitive Emotion Regulation Training via Reinterpretation
AthletesPost Activation PotentiationCountermovement Jump

Acute Effects of Different Warm-Up Protocols in Competitive Young Swimmers

RECRUITING
NCT07240597Phase NAUniversity of PalermoStarted 2025-12-02
Squats with resistance bandVertical jump after dropping from a boxCombination BS + DJ
Premenstrual Syndrome

The Effects of Manual Lymphatic Drainage and Self-Manual Lymphatic Drainage

NOT YET RECRUITING
NCT07814807Phase NAIzmir Democracy UniversityStarted 2026-10-05
Manual Lymphatic Drainage (MLD)Self-Manual Lymphatic Drainage (Self-MLD)Sham Manual Lymphatic Drainage (Sham MLD)
Kidney TransplantationFrailtyChronic Kidney Insufficiency

Prehabilitation for Kidney Transplant Candidates

RECRUITING
NCT06886256Phase NAThe Methodist Hospital Research InstituteStarted 2025-03-26
Polar H10 Heart Rate MonitorEmpatica EmbracePlusApple Watch Ultra 2
Type 2 Diabetes Mellitus (T2DM)

Effect of Tai Chi Versus Moderate-intensity Combined Exercise Training on Cardiovascular Health and Physical Functional Performance in Older Men and Women With T2DM: the Tai Chi Intervention for Diabetes Management During Aging (TIDA) Study

NOT YET RECRUITING
NCT07131761Phase NAUniversidade Estadual Paulista Júlio de Mesquita FilhoStarted 2025-08-20
Tai chiModerate-Intensity Combined Exercise (MICE)Control ( No Exercise )
Diaphragm Pacing

Effects of Combined Thoracic and Diaphragmatic Breathing on Cognitive and Psycho-Physiological Functions

NOT YET RECRUITING
NCT07620249Phase NANational Taiwan University Clinical Trial CenterStarted 2026-05-25
thoracic expansion exercises and slow diaphragmatic breathingSham Block
Physiologic MonitoringSelf-report QuestionnaireSleep Quality

Can the Belgian Coastal Environment Improve Physical and Cognitive Health in Older Adults?

ACTIVE NOT RECRUITING
NCT06893224Phase NAUniversity GhentStarted 2024-09-25
Coastal exposureUrban exposure

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients