H1-0

Chr 22

H1.0 linker histone

Also known as: H1.0, H10, H1F0, H1FV

NCBI Gene: 3005ENSG00000189060UniProt: P07305

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

51
ClinVar variants
24
Pathogenic / LP
0.64
pLI score
12
Active trials
Clinical Summary— H1-0
⚡
Population Constraint (gnomAD)
Moderately constrained gene (pLI 0.64) — some intolerance to loss-of-function variants.
📋
ClinVar Variants
24 Pathogenic / Likely Pathogenic· 23 VUS of 51 total submissions
💊
Clinical Trials
12 active or recruiting trials — potential therapeutic options may be available

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
0.90LOEUF
pLI 0.643
Z-score 1.69
OE 0.00 (0.00–0.90)
Moderately constrained

Typical tolerance to LoF variation

Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
0.88Z-score
OE missense 0.77 (0.65–0.92)
88 obs / 114.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.00 (0.00–0.90)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.77 (0.65–0.92)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.1.23
0≤1.21.6
LoF obs/exp: 0 / 3.3Missense obs/exp: 88 / 114.4Syn Z: -1.32

ClinVar Variant Classifications

51 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic22
Likely Pathogenic2
VUS23
Likely Benign3
Conflicting1
22
Pathogenic
2
Likely Pathogenic
23
VUS
3
Likely Benign
1
Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
22
0
22
Likely Pathogenic
0
0
2
0
2
VUS
0
22
1
0
23
Likely Benign
0
2
0
1
3
Benign
0
0
0
0
0
Conflicting
—1
Total02425151

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

H1-0 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Nuclear and nucleolar activity of linker histone variant H1.0.
Kowalski A·Cell Mol Biol Lett
2016Review
Novel Size-Based High-Density Lipoprotein Subspecies and Incident Vascular Events.
Deets A et al.·J Am Heart Assoc
2023
Monoclonal autoantibodies recognizing histone variants.
van Hemert FJ et al.·Immunol Invest
1988
Antimicrobial and antibiofilm activity of human recombinant H1 histones against bacterial infections.
Arévalo-Jaimes BV et al.·mSystems
2024
Neutrophil-inspired CRISPR/dCas9 nanomedicine to program self-destructing and bystander killing of tumor cell for selective cancer therapy.
Li H et al.·Biomaterials
2026
Histone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency.
Terme JM et al.·J Biol Chem
2011
Imaging analysis of six human histone H1 variants reveals universal enrichment of H1.2, H1.3, and H1.5 at the nuclear periphery and nucleolar H1X presence.
Salinas-Pena M et al.·Elife
2024
Proteasome-dependent degradation of histone H1 subtypes is mediated by its C-terminal domain.
García-Gomis D et al.·Protein Sci
2024
The H1 and core histone subtypes: differential gene expression and varied primary structures.
Doenecke D et al.·Adv Enzyme Regul
1988
A Bladder Sensor for Adults With Urinary Incontinence.
van den Bosch F et al.·Neurourol Urodyn
2025
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Breast Cancer

Water and Land-based Aerobic Training in Breast Cancer Survivors

ACTIVE NOT RECRUITING
NCT05520515Phase NAFederal University of PelotasStarted 2022-12-19
Aquatic Training Plus Health EducationLand Training Plus Health EducationHealth Education
Type 2 Diabetes

Acute Effect of Tai Chi Versus Moderate-Intensity Combined Exercise on Cardiovascular, Metabolic, and Cardiac Autonomic Control Parameters in Older Men and Women With Type 2 Diabetes Mellitus

NOT YET RECRUITING
NCT07113444Phase NAUniversidade Estadual Paulista Júlio de Mesquita FilhoStarted 2025-08-20
Tai ChiModerate-Intensity Combined Exercise (MICE)Control ( No Exercise )
Long COVIDPASC Post Acute Sequelae of COVID 19Post COVID-19 Condition (PCC)

Brain Stimulation in Long COVID

RECRUITING
NCT07278206Phase NAAmsterdam UMC, location VUmcStarted 2025-11-17
Repetitive Transcranial Magnetic StimulationSham device
Atrial Fibrillation (Paroxysmal)

Biofeedback Intervention for Paroxysmal Atrial Fibrillation

NOT YET RECRUITING
NCT07454317Phase NALiverpool John Moores UniversityStarted 2026-03-16
Biofeedback intervention
Performance

Effect of Acute Phenylcapsaicin Intake on Trained Cross-Training Athletes

ACTIVE NOT RECRUITING
NCT06784271Phase NAUniversidad de GranadaStarted 2024-12-02
PhenylcapsaicinPlacebo
Chronic Shoulder PainRotator Cuff Related Shoulder PainFrozen Shoulder

HIIT for Inflammatory-driven Shoulder Pain.

RECRUITING
NCT07275164Phase NAUniversiteit AntwerpenStarted 2025-12-10
High intensity interval training (HIIT)
Multiple Myeloma (MM)Breathing TechniquesBreathing Exercises

Effects of Controlled Breathing on Cardiorespiratory Variables in Multiple Myeloma

NOT YET RECRUITING
NCT07376733Phase NAUniversidad Complutense de MadridStarted 2026-01
Controlled breathing exercise protocol + therapeutic exercise + initial education sessionTherapeutic exercise + initial education session
Breast BiopsyAnxietyPain

Virtual Reality vs. Music Relaxation for Reducing Anxiety and Pain During Breast Biopsies

RECRUITING
NCT07310004Phase NAJonsson Comprehensive Cancer CenterStarted 2026-01-20
Virtual Reality (VR) Mindful AppStandard Calming Music
Prediabetes

Effects of a Mediterranean Diet With Cycling and Rowing Exercise on Blood Sugar in Women With Prediabetes

ENROLLING BY INVITATION
NCT07326891Phase NABegüm Yücesoy GüneysuStarted 2025-12-15
Mediterranean DietSupervised Sequential Exercise
Ovarian CarcinomaFirst Line ChemotherapyDigestive System Disorders

Benefit of Transcutaneous Auricular Vagus Nerve Stimulation in Improving Quality of Life in First Line Treatment of Ovarian Cancer:

RECRUITING
NCT06817161Phase PHASE3Centre Francois BaclesseStarted 2025-04-30
transcutaneous auricular vagus nerve stimulationPlacebo device
Stress, PhysiologicalStress, PsychologicalInflammatory Response

Daoist Zhanzhuang and Human Flourishing

RECRUITING
NCT06573034Phase NAUniversity of North Carolina, CharlotteStarted 2024-08-29
Daoist ZhanzhuangSham Wall Squat
Anxiety

The Effectiveness of Press Needle Acupuncture on Preoperative Anxiety in Tympanoplasty and Mastoidectomy

RECRUITING
NCT07278284Phase NAIndonesia UniversityStarted 2026-01-18
The press needle acupunctureThe sham press needle acupuncture

External Resources

Links to major genomics databases and tools