LGALS2

Chr 22

galectin 2

Also known as: HL14

NCBI Gene: 3957ENSG00000100079UniProt: P05162

The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
1
Active trials
10
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.48
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.48LOEUF
pLI 0.020
Z-score 0.86
OE 0.59 (0.27–1.48)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.36Z-score
OE missense 1.12 (0.94–1.34)
83 obs / 74.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.59 (0.27–1.48)
0≤0.351.4
Missense OE?1.12 (0.94–1.34)
0≤0.61.4
Synonymous OE?1.07
0≤1.21.6
LoF obs/exp: 3 / 5.1Missense obs/exp: 83 / 74.2Syn Z: -0.31

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

LGALS2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients