C1QTNF6

Chr 22

C1q and TNF related 6

Also known as: CTFP6, CTRP6, ZACRP6

NCBI Gene: 114904ENSG00000133466UniProt: Q9BXI9

Enables identical protein binding activity. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Predicted to be active in obsolete extracellular space. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
11
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.62
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.62LOEUF
pLI 0.000
Z-score 0.21
OE 0.92 (0.54–1.62)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.51Z-score
OE missense 0.89 (0.79–1.02)
168 obs / 187.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.92 (0.54–1.62)
0≤0.351.4
Missense OE?0.89 (0.79–1.02)
0≤0.61.4
Synonymous OE?0.85
0≤1.21.6
LoF obs/exp: 8 / 8.7Missense obs/exp: 168 / 187.8Syn Z: 1.08

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

C1QTNF6 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients