Genes associated with “LISX2”

33 genes foundOpen Targets: X-linked lissencephaly with abnormal genitalia
How are genes scored? (0–100 composite)
-5–15
ClinGen
0–15
HPO Freq
0–15
Open Targets
0–12
Phen2Gene
0–10
ClinVar
0–8
Constraint
0–8
Dosage
0–8
OMIM CS
0–8
PanelApp
0–5
OMIM
0–5
G2P
0–4
Breadth
Tiers:Strong Candidates (≥20)Consider (≥8)Possible (≥3)
Evidence dots:
HPOClinVarPhen2GeneOpen TargetsPanelApp
hover for details

Strong Candidates

1 gene
1
ARX →

aristaless related homeobox

35
score
ClinGen: DefinitiveGTR ↑

Developmental and epileptic encephalopathy 1

Frequency
-
P/LP Variants
50
OT Score
0.81

Consider

5 genes
13DMD
Def
13IL1RAPL1
Def
13LISX2

LISSENCEPHALY, X-LINKED, 2; LISX2

10NR0B1
10POLA1
Mod

Possible

19 genes — click to expand
5MSX1
Def

msh homeobox 1

5GATA3
Def

GATA binding protein 3

5SATB2
Def

SATB homeobox 2

5DCX
Def

doublecortin

4BNC2

basonuclin zinc finger protein 2

4DCAF8L1
4DCAF8L2
4FTHL17
4MAGEB1
4MAGEB10
4MAGEB18
4MAGEB2
4MAGEB3
4MAGEB4
4MAGEB5
4MAGEB6
4TAB3
3SEC23B
Def

SEC23 homolog B, COPII component

3TUBA1A
Def

tubulin alpha 1a

Related phenotype searches

Intellectual disabilityGlobal developmental delaySpeech/language delayNeurodegenerationDevelopmental regressionSeizuresEpileptic encephalopathyStatus epilepticus

Data aggregated from HPO/Monarch, ClinVar, OMIM (phenotypes + clinical synopsis), Open Targets, PanelApp, Phen2Gene, and Gene2Phenotype. Click a gene to view full details.