DCAF8L2

Chr X

DDB1 and CUL4 associated factor 8 like 2

Also known as: WDR42C

NCBI Gene: 347442 ENSG00000189186 UniProt: P0C7V8

The protein is predicted to function as part of the Cul4-RING E3 ubiquitin ligase complex and localizes to the nucleus and cytoplasm. No definitive disease associations have been established for DCAF8L2 mutations. The gene shows high intolerance to loss-of-function variants (pLI 0.82, LOEUF 0.47), suggesting it may be essential for normal development.

ResearchSummary from RefSeq

Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.47

LOEUF

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Mechanism