DCAF8L2
Chr XDDB1 and CUL4 associated factor 8 like 2
Also known as: WDR42C
Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
ResearchGenerating clinical summary…
LOEUF 0.47
Clinical Summary— DCAF8L2
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Population Constraint (gnomAD)
Moderately constrained gene (pLI 0.82) — some intolerance to loss-of-function variants.
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Moderate LoF intolerance
LoF Constraint?
0.47LOEUF
pLI 0.819
Z-score 2.64
OE 0.10 (0.03–0.47)
More LoF-intolerant than ~75% of genes
Missense Constraint?
1.34Z-score
OE missense 0.76 (0.68–0.86)
190 obs / 249.8 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.10 (0.03–0.47)
0≤0.351.4
Missense OE?0.76 (0.68–0.86)
0≤0.61.4
Synonymous OE?1.09
0≤1.21.6
LoF obs/exp: 1 / 10.0Missense obs/exp: 190 / 249.8Syn Z: -0.67
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
DCAF8L2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools