DCAF8L2
Chr XDDB1 and CUL4 associated factor 8 like 2
Also known as: WDR42C
The protein is predicted to function as part of the Cul4-RING E3 ubiquitin ligase complex and localizes to the nucleus and cytoplasm. No definitive disease associations have been established for DCAF8L2 mutations. The gene shows high intolerance to loss-of-function variants (pLI 0.82, LOEUF 0.47), suggesting it may be essential for normal development.
Some data sources returned errors (1)
ensembl: TimeoutError: The operation was aborted due to timeout
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
DCAF8L2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools