ZSCAN16

Chr 6

zinc finger and SCAN domain containing 16

Also known as: ZNF392, ZNF435, dJ265C24.3

NCBI Gene: 80345ENSG00000196812UniProt: Q9H4T2

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.46
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.46LOEUF
pLI 0.000
Z-score 0.38
OE 0.88 (0.56–1.46)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.79Z-score
OE missense 0.84 (0.73–0.96)
154 obs / 184.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.88 (0.56–1.46)
0≤0.351.4
Missense OE?0.84 (0.73–0.96)
0≤0.61.4
Synonymous OE?0.81
0≤1.21.6
LoF obs/exp: 11 / 12.4Missense obs/exp: 154 / 184.1Syn Z: 1.21

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZSCAN16 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients