ZSCAN12

Chr 6

zinc finger and SCAN domain containing 12

Also known as: ZFP96, ZNF29K1, ZNF305, ZNF96, dJ29K1.2

NCBI Gene: 9753ENSG00000158691UniProt: O43309

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.87
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.87LOEUF
pLI 0.000
Z-score 2.09
OE 0.56 (0.38–0.87)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.90Z-score
OE missense 0.70 (0.63–0.78)
222 obs / 317.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.56 (0.38–0.87)
0≤0.351.4
Missense OE?0.70 (0.63–0.78)
0≤0.61.4
Synonymous OE?0.69
0≤1.21.6
LoF obs/exp: 15 / 26.7Missense obs/exp: 222 / 317.5Syn Z: 2.56

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZSCAN12 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients