ZNG1F
Chr 9Zn regulated GTPase metalloprotein activator 1F
Also known as: CBWD6, CBWD7
ZNG1F encodes a zinc chaperone that transfers zinc cofactor to target metalloproteins, specifically catalyzing zinc insertion into methionine aminopeptidase METAP1 through GTP hydrolysis to activate protein processing during translation. Based on the provided information, no disease associations or inheritance patterns have been established for this gene. The protein functions in both the nucleus and cytoplasm as part of essential cellular zinc homeostasis pathways.
Population Genetics & Constraint
Constraint data not available from gnomAD.
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZNG1F · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools