ZNG1F

Chr 9

Zn regulated GTPase metalloprotein activator 1F

Also known as: CBWD6, CBWD7

NCBI Gene: 644019 ENSG00000215126 UniProt: Q4V339 OMIM: 621673

ZNG1F encodes a zinc chaperone that transfers zinc cofactor to target metalloproteins, specifically catalyzing zinc insertion into methionine aminopeptidase METAP1 through GTP hydrolysis to activate protein processing during translation. Based on the provided information, no disease associations or inheritance patterns have been established for this gene. The protein functions in both the nucleus and cytoplasm as part of essential cellular zinc homeostasis pathways.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to enable zinc chaperone activity and zinc ion binding activity. Predicted to be involved in protein maturation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

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LOEUF

Mechanism· predicted

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in ZNG1F?

gnomAD v4 · ~728k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 150

134 rare PASS variants

Rare truncating (LoF)

1 in 560

23 rare PASS variants

Rare synonymous (reference)

1 in 1,100

46 rare PASS variants

Rare missense and truncating variants are carried at similar rates in ZNG1F; this gene does not show strong loss-of-function constraint by this measure. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~554k	1 in 210	1 in 1,100
South Asian	~43k	1 in 280	1 in 630
Remaining (unassigned)	~30k	1 in 150	1 in 1,300
European (Finnish)	~27k	1 in 1,200	1 in 2,600
Admixed American	~22k	1 in 140	1 in 610
African / African American	~21k	1 in 140	1 in 920
East Asian	~20k	1 in 150	1 in 640
Ashkenazi Jewish	~13k	1 in 670	≈ 1 in 4,900
Middle Eastern	~2,864	1 in 170	none seen

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 5 of 15 coding exons well covered in gnomAD exomes; exons 1, 2, 4, 6, 7 and 4 more poorly covered; exon 13 marginal. Genomes: 0 of 15 (exons 1, 2, 3, 4, 5 and 10 more below).? see exons ↓