ZNG1C

Chr 9

Zn regulated GTPase metalloprotein activator 1C

Also known as: CBWD3, bA561O23.1

ZNG1C encodes a zinc chaperone that transfers zinc cofactor to target metalloproteins, specifically catalyzing zinc insertion into methionine aminopeptidase METAP1 to activate its function in cleaving initiator methionine from newly synthesized proteins. The gene is highly constrained against loss-of-function variants (pLI near 1.0), suggesting that mutations would likely cause severe developmental disorders, though specific associated phenotypes have not yet been established in humans. Any resulting condition would be expected to follow an autosomal recessive inheritance pattern given the gene's tolerance metrics.

OMIMResearchSummary from RefSeq, UniProt
DNmechanismLOEUF 1.89
Clinical SummaryZNG1C
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.89LOEUF
pLI 0.000
Z-score -0.64
OE 1.28 (0.731.89)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
0.22Z-score
OE missense 0.91 (0.711.18)
41 obs / 45.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE1.28 (0.731.89)
00.351.4
Missense OE0.91 (0.711.18)
00.61.4
Synonymous OE1.30
01.21.6
LoF obs/exp: 8 / 6.3Missense obs/exp: 41 / 45.1Syn Z: -0.98
DN
0.74top 25%
GOF
0.6346th %ile
LOF
0.2678th %ile

The highest-scoring mechanism for this gene is dominant-negative.

DNprediction above median

Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ZNG1C · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found