ZNF92

Chr 7

zinc finger protein 92

Also known as: HEL-203, HPF12, HTF12, TF12

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.84
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.84LOEUF
pLI 0.000
Z-score -0.23
OE 1.11 (0.591.84)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.29Z-score
OE missense 0.95 (0.861.05)
280 obs / 294.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.11 (0.591.84)
00.351.4
Missense OE?0.95 (0.861.05)
00.61.4
Synonymous OE?0.92
01.21.6
LoF obs/exp: 6 / 5.4Missense obs/exp: 280 / 294.0Syn Z: 0.62

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ZNF92 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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