ZNF853

Chr 7

zinc finger protein 853

NCBI Gene: 54753 ENSG00000236609 UniProt: P0CG23

The protein functions as a DNA-binding transcription factor that regulates RNA polymerase II-mediated gene transcription. ZNF853 is highly constrained against loss-of-function variants, but no definitive human disease associations have been established for mutations in this gene. The inheritance pattern for potential ZNF853-related disorders has not been determined.

ResearchSummary from RefSeq

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

0.52

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

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