ZNF804A
Chr 2zinc finger protein 804A
Also known as: C2orf10
The protein is a zinc finger DNA-binding protein that regulates gene expression. This gene is highly constrained against loss-of-function variants (pLI 0.006, LOEUF 0.48), and polymorphisms are associated with increased susceptibility to schizophrenia, bipolar disorder, and heroin addiction. The inheritance pattern for pathogenic variants in pediatric neurogenetic disorders has not been established.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Tolerant to missense variation
ClinVar Variant Classifications
235 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 25 | 0 | 25 |
Likely Pathogenic | 0 | 0 | 1 | 0 | 1 |
VUS | 1 | 158 | 4 | 0 | 163 |
Likely Benign | 0 | 17 | 4 | 3 | 24 |
Benign | 0 | 9 | 1 | 6 | 16 |
Conflicting | — | 1 | |||
| Total | 1 | 184 | 35 | 9 | 230 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
ZNF804A · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools