ZNF79

Chr 9

zinc finger protein 79

Also known as: pT7

NCBI Gene: 7633 ENSG00000196152 UniProt: Q15937 OMIM: 194552

ZNF79 encodes a zinc finger transcription factor that binds DNA and regulates RNA polymerase II-mediated transcription in the nucleus. The gene shows low constraint against loss-of-function variants (pLI = 0.007, LOEUF = 0.69), and no definitive disease associations have been established in humans. Clinical significance of variants in this gene remains uncertain.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.69

LOEUF

Multiple*

Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

0.69LOEUF

pLI 0.007

Z-score 2.57

OE 0.37 (0.21–0.69)

Tolerant

Typical tolerance to LoF variation

Missense Constraint?

0.21Z-score

OE missense 0.97 (0.87–1.07)

271 obs / 280.7 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?0.37 (0.21–0.69)

0≤0.351.4

Missense OE?0.97 (0.87–1.07)

0≤0.61.4

Synonymous OE?1.10

0≤1.21.6

LoF obs/exp: 7 / 19.2Missense obs/exp: 271 / 280.7Syn Z: -0.85

Background carrier burden — how many people carry a rare variant somewhere in ZNF79?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 95

671 rare PASS variants

Rare truncating (LoF)

1 in 1,100

105 rare PASS variants

Rare synonymous (reference)

1 in 130

237 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for ZNF79. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 120	1 in 1,300
South Asian	~43k	1 in 68	1 in 400
Remaining (unassigned)	~30k	1 in 82	1 in 2,000
European (Finnish)	~27k	1 in 470	1 in 5,200
Admixed American	~22k	1 in 110	1 in 1,600
African / African American	~21k	1 in 79	1 in 860
East Asian	~20k	1 in 79	1 in 650
Ashkenazi Jewish	~13k	1 in 360	≈ 1 in 4,300
Middle Eastern	~2,884	1 in 110	≈ 1 in 2,900

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 5 coding exons well covered in gnomAD exomes and genomes.? see exons ↓