ZNF785

Chr 16

zinc finger protein 785

NCBI Gene: 146540ENSG00000197162UniProt: A8K8V0

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.94
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.94LOEUF
pLI 0.000
Z-score -1.16
OE 1.60 (0.83–1.94)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.53Z-score
OE missense 0.91 (0.82–1.01)
250 obs / 274.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.60 (0.83–1.94)
0≤0.351.4
Missense OE?0.91 (0.82–1.01)
0≤0.61.4
Synonymous OE?0.85
0≤1.21.6
LoF obs/exp: 7 / 4.4Missense obs/exp: 250 / 274.6Syn Z: 1.22

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZNF785 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients