ZNF770

Chr 15

zinc finger protein 770

Also known as: PRO1914

NCBI Gene: 54989 ENSG00000198146 UniProt: Q6IQ21

Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jun 2026]

Research

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.28

LOEUF· LoF intol.

LOF

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

LoF intolerant — likely haploinsufficient

LoF Constraint?

0.28LOEUF

pLI 0.991

Z-score 4.04

OE 0.09 (0.04–0.28)

Highly constrained

Highly LoF-intolerant (top ~10% of genes)

Missense Constraint?

0.84Z-score

OE missense 0.87 (0.79–0.96)

305 obs / 349.2 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?0.09 (0.04–0.28)

0≤0.351.4

Missense OE?0.87 (0.79–0.96)

0≤0.61.4

Synonymous OE?1.27

0≤1.21.6

LoF obs/exp: 2 / 22.9Missense obs/exp: 305 / 349.2Syn Z: -2.34

Background carrier burden — how many people carry a rare variant somewhere in ZNF770?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 91

753 rare PASS variants

Rare truncating (LoF)

1 in 4,900

46 rare PASS variants

Rare synonymous (reference)

1 in 110

327 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for ZNF770. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 130	1 in 4,200
South Asian	~43k	1 in 100	1 in 6,200
Remaining (unassigned)	~30k	1 in 88	1 in 5,000
European (Finnish)	~27k	1 in 720	≈ 1 in 6,700
Admixed American	~22k	1 in 88	none seen
African / African American	~21k	1 in 76	≈ 1 in 21,000
East Asian	~20k	1 in 78	≈ 1 in 6,600
Ashkenazi Jewish	~13k	1 in 420	≈ 1 in 13,000
Middle Eastern	~2,884	1 in 130	none seen

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 1 coding exons well covered in gnomAD exomes and genomes.? see exons ↓