ZNF75A

Chr 16

zinc finger protein 75A

NCBI Gene: 7627ENSG00000162086UniProt: Q96N20OMIM: 601473

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.00
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.00LOEUF
pLI 0.002
Z-score 1.57
OE 0.51 (0.28–1.00)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.01Z-score
OE missense 1.00 (0.88–1.14)
154 obs / 154.2 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.51 (0.28–1.00)
0≤0.351.4
Missense OE?1.00 (0.88–1.14)
0≤0.61.4
Synonymous OE?1.13
0≤1.21.6
LoF obs/exp: 6 / 11.8Missense obs/exp: 154 / 154.2Syn Z: -0.74

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ZNF75A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients