ZNF74

Chr 22

zinc finger protein 74

Also known as: COS52, ZFP520, ZNF520, hZNF7

NCBI Gene: 7625 ENSG00000185252 UniProt: Q16587 OMIM: 194548

The ZNF74 protein functions as a DNA-binding transcription factor that regulates RNA polymerase II-mediated transcription and may be involved in RNA metabolism. This gene is highly constrained against loss-of-function variants (pLI ~1.0), suggesting that mutations would likely cause severe developmental effects, though no specific disease associations have been established in the clinical literature to date.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.89

LOEUF

Multiple*

Mechanism· predicted