ZNF710

Chr 15

zinc finger protein 710

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
LOFmechanismLOEUF 0.28
Clinical SummaryZNF710
Population Constraint (gnomAD)
Highly constrained gene — heterozygous loss-of-function variants are very rare in the population (pLI 0.99). One damaged copy is likely sufficient to cause disease.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

LoF intolerant — likely haploinsufficient
LoF Constraint?
0.28LOEUF
pLI 0.990
Z-score 4.02
OE 0.09 (0.040.28)
Highly constrained

Highly LoF-intolerant (top ~10% of genes)

Missense Constraint?
2.42Z-score
OE missense 0.68 (0.620.75)
305 obs / 449.1 exp
Mild constraint

Moderately missense-constrained (top ~2.5%)

Observed / Expected Ratios?
LoF OE?0.09 (0.040.28)
00.351.4
Missense OE?0.68 (0.620.75)
00.61.4
Synonymous OE?0.96
01.21.6
LoF obs/exp: 2 / 22.7Missense obs/exp: 305 / 449.1Syn Z: 0.45

This gene — mechanism propensity

DN
0.4090th %ile
GOF
0.3590th %ile
LOF
0.73top 10%

The highest-scoring mechanism for this gene is loss-of-function (haploinsufficiency).

LOFprediction above median · LOEUF 0.28

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312. Mechanism ranking also informed by gnomAD constraint, ClinVar, and ClinGen data.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ZNF710 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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