ZNF703

Chr 8

zinc finger protein 703

Also known as: NLZ1, ZEPPO1, ZNF503L, ZPO1

NCBI Gene: 80139 ENSG00000183779 UniProt: Q9H7S9 OMIM: 617045

Predicted to enable DNA-binding transcription factor binding activity and zinc ion binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of mammary gland epithelial cell proliferation; and regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nuclear matrix. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

OMIM Research

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

—

LOEUF

LOF

Mechanism· predicted

Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 400

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in ZNF703?

gnomAD v4 · ~730k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 84

889 rare PASS variants

Rare truncating (LoF)

1 in 7,300

50 rare PASS variants

Rare synonymous (reference)

1 in 120

502 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for ZNF703. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 100	1 in 13,000
South Asian	~43k	1 in 96	1 in 3,600
Remaining (unassigned)	~30k	1 in 81	≈ 1 in 15,000
European (Finnish)	~26k	1 in 220	1 in 2,900
Admixed American	~22k	1 in 77	1 in 3,300
African / African American	~21k	1 in 85	1 in 2,800
East Asian	~20k	1 in 68	1 in 3,100
Ashkenazi Jewish	~13k	1 in 450	≈ 1 in 12,000
Middle Eastern	~2,884	1 in 81	none seen

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.