ZNF7

Chr 8

zinc finger protein 7

Also known as: HF.16, KOX4, zf30

NCBI Gene: 7553 ENSG00000147789 UniProt: P17097 OMIM: 194531

ZNF7 encodes a zinc finger transcription factor that regulates gene expression by binding to specific DNA sequences and modulating RNA polymerase II transcription. The gene is not loss-of-function intolerant (pLI near 0, LOEUF 0.867), suggesting it may tolerate some degree of functional variation. Currently, no definitive disease associations have been established for ZNF7 mutations in clinical practice.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.87

LOEUF

Multiple*

Mechanism· predicted