ZNF695

Chr 1

zinc finger protein 695

Also known as: SBZF3

NCBI Gene: 57116 ENSG00000197472 UniProt: Q8IW36

The protein is predicted to function as a DNA-binding transcription factor that regulates gene expression by binding to specific DNA sequences and controlling RNA polymerase II-mediated transcription in the nucleus. Currently, no established human diseases have been definitively linked to mutations in this gene. The gene appears to be tolerant to loss-of-function variants based on constraint metrics, suggesting that complete loss of function may not cause severe developmental phenotypes.

ResearchSummary from RefSeq, UniProt

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.85

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)