ZNF692

Chr 1

zinc finger protein 692

Also known as: AREBP, Zfp692

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of gluconeogenesis. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
6
Pubs (1 yr)
P/LP submissions
P/LP missense
1.22
LOEUF
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.22LOEUF
pLI 0.000
Z-score 0.75
OE 0.83 (0.581.22)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.85Z-score
OE missense 0.86 (0.780.96)
257 obs / 298.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.83 (0.581.22)
00.351.4
Missense OE?0.86 (0.780.96)
00.61.4
Synonymous OE?1.05
01.21.6
LoF obs/exp: 19 / 22.8Missense obs/exp: 257 / 298.1Syn Z: -0.41

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ZNF692 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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