ZNF691
Chr 1zinc finger protein 691
ZNF691 encodes a transcription factor that binds DNA and regulates gene expression by RNA polymerase II in the nucleus. The gene is highly constrained against loss-of-function variants (pLI 0.82, LOEUF 0.47), suggesting that mutations would likely cause significant developmental consequences. However, no specific disease associations have been established for this gene in current databases.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZNF691 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools