ZNF679

Chr 7

zinc finger protein 679

NCBI Gene: 168417 ENSG00000197123 UniProt: Q8IYX0

The ZNF679 protein functions as a DNA-binding transcription factor that regulates gene expression by binding to specific DNA sequences and controlling RNA polymerase II-mediated transcription in the nucleus. Currently, no established human diseases have been definitively linked to ZNF679 mutations in the medical literature. The gene shows relatively low constraint against loss-of-function variants (pLI 0.18, LOEUF 0.98), suggesting it may be more tolerant of genetic variation than highly disease-associated genes.

ResearchSummary from RefSeq, UniProt

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.98

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429