ZNF669

Chr 1

zinc finger protein 669

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.46
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.46LOEUF
pLI 0.001
Z-score 0.74
OE 0.70 (0.361.46)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.67Z-score
OE missense 1.12 (1.011.23)
283 obs / 253.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.70 (0.361.46)
00.351.4
Missense OE?1.12 (1.011.23)
00.61.4
Synonymous OE?1.19
01.21.6
LoF obs/exp: 5 / 7.1Missense obs/exp: 283 / 253.0Syn Z: -1.45

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ZNF669 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →