ZNF668
Chr 16ARzinc finger protein 668
Also known as: NEDGEF
ZNF668 encodes a zinc finger transcription factor that functions as a DNA-binding transcriptional repressor and is involved in DNA repair processes. Autosomal recessive mutations cause a neurodevelopmental disorder characterized by poor growth, large ears, and dysmorphic facial features. This gene shows moderate constraint against loss-of-function variants (LOEUF 0.52), consistent with its role in essential cellular processes.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ZNF668 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools