ZNF629

Chr 16

zinc finger protein 629

Also known as: ZNF, ZNF65

NCBI Gene: 23361 ENSG00000102870 UniProt: Q9UEG4

This protein is predicted to regulate transcription by RNA polymerase II through DNA binding and zinc ion binding activities in the nucleus. The gene is highly constrained against loss-of-function variants (pLI = 1.00, LOEUF = 0.17), suggesting mutations would likely cause severe disease, though specific associated disorders have not yet been established. Any pathogenic variants would be expected to follow autosomal dominant inheritance given the extreme constraint metrics.

ResearchSummary from RefSeq, UniProt

Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.17

LOEUF· LoF intol.

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

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