ZNF623

Chr 8

zinc finger protein 623

NCBI Gene: 9831 ENSG00000183309 UniProt: O75123

The ZNF623 protein is predicted to function as a DNA-binding transcription factor that regulates gene expression by RNA polymerase II in the nucleus. This gene has very low constraint against loss-of-function variants (pLI ~0, LOEUF 1.15), suggesting it tolerates protein-disrupting mutations well. No established human diseases have been definitively linked to ZNF623 mutations in the medical literature.

ResearchSummary from RefSeq, UniProt

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.15

LOEUF

Multiple*

Mechanism· predicted